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Gt(ROSA)26Sortm1(CAG-CAMK2G*T287D,-EGFP)Whua
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(CAG-CAMK2G*T287D,-EGFP)Whua
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Wendong Huang
MGI ID: MGI:5927425
Synonyms: CA-CAMK2gamma fl
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:243363
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(CAG-CAMK2G*T287D,-EGFP)Whua expresses 1 gene
 
Mutation detailsA conditional human CAMK2G (isoform 3) over-expression cassette containing a T-to-D mutation at Thr287 (T287D) and a loxP-flanked STOP and a frt-flanked IRES-EGFP under the control of the CAG promoter was inserted into the locus. The T287D mutation allows for constitutive activation of the gene. (J:243363)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  513 strains or lines available
References
Original:  J:243363 Ma X, et al., CAMK2gamma in intestinal epithelial cells modulates colitis-associated colorectal carcinogenesis via enhancing STAT3 activation. Oncogene. 2017 Jul 13;36(28):4060-4071
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory