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Lrig3tm1.1Hhed
Targeted Allele Detail
Nomenclature
Symbol: Lrig3tm1.1Hhed
Name: leucine-rich repeats and immunoglobulin-like domains 3; targeted mutation 1.1, Hakan Hedman
MGI ID: MGI:5911996
Gene: Lrig3  Location: Chr10:125966219-126015359 bp, + strand  Genetic Position: Chr10, 73.66 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:242435
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and a neomycin resistance gene cassette and a second loxP site were inserted into intron 1. Exon 1 was deleted through subsequent cre-mediated recombination. Western blots and RT-PCR confirmed the lack of expression from the knockout allele. (J:242435)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrig3 Mutation:  48 strains or lines available
References
Original:  J:242435 Hellstrom M, et al., Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2016 Jun 01;310(11):R1045-52
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory