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Targeted Allele Detail
Symbol: Meis2tm1.2Zkoz
Name: Meis homeobox 2; targeted mutation 1.2, Zbynek Kozmik
MGI ID: MGI:5911948
Gene: Meis2  Location: Chr2:115863064-116065839 bp, - strand  Genetic Position: Chr2, 58.28 cM
Germline Transmission:  Earliest citation of germline transmission: J:229604
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6J)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3 through 6 were floxed and an FRT flanked neo cassette was inserted via homologous recombination. Flp-mediated recombination removed the neo cassette. Cre mediated recombination removed exons 3-6. Western blot analysis confirmed the absence of protein expression in homozygous embryos. (J:229604)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Meis2 Mutation:  4 strains or lines available
Original:  J:229604 Machon O, et al., Meis2 is essential for cranial and cardiac neural crest development. BMC Dev Biol. 2015;15:40
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory