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Srcinl
Spontaneous Allele Detail
Nomenclature
Symbol: Srcinl
Name: Rous sarcoma oncogene; incisor-less
MGI ID: MGI:5911893
Synonyms: Srcthl, thl, toothless
Gene: Src  Location: Chr2:157423906-157471838 bp, + strand  Genetic Position: Chr2, 78.35 cM
Mutation
origin
Strain of Origin:  129
Mutation
description
Allele Type:    Spontaneous (Null/knockout)
Mutation:    Insertion
 
Mutation detailsAn insertion or duplication of a C nucleotide (coding nucleotide 1159 in transcript NM_009271 or ENSMUST00000092576) was detected in exon 12, resulting in a frameshift and premature stop codon. Immunoblotting failed to detect wild-type protein or the predicted truncated protein in whole brain lysates from homozygous mice. (J:229610)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Src Mutation:  121 strains or lines available
References
Original:  J:229610 Sinai L, et al., Disruption of Src Is Associated with Phenotypes Related to Williams-Beuren Syndrome and Altered Cellular Localization of TFII-I(1,2). eNeuro. 2015 Mar-Apr;2(2)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory