Runx3^{tm6(EGFP/cre)Yg}
Targeted Allele Detail

Summary

• Symbol: Runx3^{tm6(EGFP/cre)Yg}
• Name: runt related transcription factor 3; targeted mutation 6, Yoram Groner
• MGI ID: MGI:5911702
• Synonyms: Runx3^Cre
• Gene: Runx3 Location: Chr4:134847963-134905301 bp, + strand Genetic Position: Chr4, 67.19 cM
• Alliance: Runx3^{tm6(EGFP/cre)Yg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241125
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Runx3^{tm6(EGFP/cre)Yg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Runx3 (MGI:102672)

• Mutation details: A EGFP-Cre-CSF-PolyAfrt-Pgk/neo-frt cassette was inserted in-frame into exon 4 via homologous recombination in ES cells. (J:241125)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Runx3 (mouse) Summary of all recombinase alleles driven by Runx3. Alliance mouse Runx3 gene page

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx3 Mutation: 24 strains or lines available

References

• Original: J:241125 Levanon D, et al., Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function. EMBO Mol Med. 2011 Oct;3(10):593-604
• All: 3 reference(s)