Ythdc2^em1Chhe
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ythdc2^em1Chhe
• Name: YTH domain containing 2; endonuclease-mediated mutation 1, Chuan He
• MGI ID: MGI:5911671
• Gene: Ythdc2 Location: Chr18:44961521-45022787 bp, + strand Genetic Position: Chr18, 23.81 cM
• Alliance: Ythdc2^em1Chhe page

Mutation origin

• Strain of Origin: (BALB/c x C57BL/6)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CIRSPR/Cas9 technology introduced a 37 bp deletion in exon 5. (J:243743)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ythdc2 Mutation: 58 strains or lines available

References

• Original: J:243743 Hsu PJ, et al., Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis. Cell Res. 2017 Sep;27(9):1115-1127
• All: 1 reference(s)