Tg(Myh6-Tnni3*L184)#Rste
Transgene Detail
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Symbol: |
Tg(Myh6-Tnni3*L184)#Rste |
Name: |
transgene insertion, Robert Stehle |
MGI ID: |
MGI:5910501 |
Synonyms: |
TG-deltaK184 |
Transgene: |
Tg(Myh6-Tnni3*L184)#Rste Location: unknown
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Alliance: |
Tg(Myh6-Tnni3*L184)#Rste page
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Strain of Origin: |
C57BL/6 x DBA/2
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Myh6-Tnni3*L184)#Rste expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Tnni3 (MGI:98783) |
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Mutation details: The murine cardiac troponin I carrying a deletion of a lysine residue at codon 184 in the C-terminal mobile domain is under the control of the murine alpha-myosin heavy chain promoter. More than 90% of the mouse wild-type protein is replaced by the transgenic protein in isolated cardiac myofibrils from transgenic mice. The pound symbol (#) is used when line is not specified and/or lines are pooled.
(J:161911)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:161911 Iorga B, et al., Lys184 deletion in troponin I impairs relaxation kinetics and induces hypercontractility in murine cardiac myofibrils. Cardiovasc Res. 2008 Mar 1;77(4):676-86 |
All: |
1 reference(s) |
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