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Gsdmdem1Flv
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Gsdmdem1Flv
Name: gasdermin D; endnuclease mediated mutation 1, Richard Flavell
MGI ID: MGI:5910442
Gene: Gsdmd  Location: Chr15:75862327-75867408 bp, + strand  Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 2 through part of exon 8 were deleted using sgRNAs and CRIPSR-Cas9 methods. qRT-PCR validation using intestine tissues showed that no detectable full length trasnscript is expressed from this allele. (J:243487)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gsdmd Mutation:  9 strains or lines available
References
Original:  J:243487 Zhu S, et al., Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017 Jun 29;546(7660):667-670
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory