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Endonuclease-mediated Allele Detail
Symbol: Nlrp9bem1Flv
Name: NLR family, pyrin domain containing 9B; endonuclease mediated mutation 1, Richard Flavell
MGI ID: MGI:5910440
Gene: Nlrp9b  Location: Chr7:19991393-20062942 bp, + strand  Genetic Position: Chr7, 9.96 cM
Strain of Origin:  C57BL/6N
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 2 and part of exon 3 were deleted using sgRNAs and the CRISPR/Cas9 system. This region contains the common translation initiation codon for two different isoforms of the encoded protein. qRT-PCR validation using intestine tissues showed that no detectable full length transcript is expressed from this allele. (J:243487)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nlrp9b Mutation:  26 strains or lines available
Original:  J:243487 Zhu S, et al., Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017 Jun 29;546(7660):667-670
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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