About   Help   FAQ
Nlrp9bem1Flv
Endonuclease-mediated Allele Detail
Summary
Symbol: Nlrp9bem1Flv
Name: NLR family, pyrin domain containing 9B; endonuclease-mediated mutation 1, Richard Flavell
MGI ID: MGI:5910440
Gene: Nlrp9b  Location: Chr7:19725318-19796867 bp, + strand  Genetic Position: Chr7, 9.96 cM
Alliance: Nlrp9bem1Flv page
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 2 and part of exon 3 were deleted using sgRNAs and the CRISPR/Cas9 system. This region contains the common translation initiation codon for two different isoforms of the encoded protein. qRT-PCR validation using intestine tissues showed that no detectable full length transcript is expressed from this allele. (J:243487)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nlrp9b Mutation:  51 strains or lines available
References
Original:  J:243487 Zhu S, et al., Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017 Jun 29;546(7660):667-670
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory