Acaca^tm1Jdh
Targeted Allele Detail

Summary

• Symbol: Acaca^tm1Jdh
• Name: acetyl-Coenzyme A carboxylase alpha; targeted mutation 1, Jay D Horton
• MGI ID: MGI:5909418
• Synonyms: ACC1^fl
• Gene: Acaca Location: Chr11:84020498-84292477 bp, + strand Genetic Position: Chr11, 51.29 cM
• Alliance: Acaca^tm1Jdh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253561
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector contains a loxP site inserted in intron 21 and a loxP-flanked neomycin cassette inserted in intron 26. (J:253561)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acaca Mutation: 124 strains or lines available

References

• Original: J:253561 Kim CW, et al., Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation. Cell Metab. 2017 Aug 1;26(2):394-406.e6
• All: 2 reference(s)