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Targeted Allele Detail
Symbol: Acacatm1Jdh
Name: acetyl-Coenzyme A carboxylase alpha; targeted mutation 1, Jay D Horton
MGI ID: MGI:5909418
Synonyms: ACC1fl
Gene: Acaca  Location: Chr11:84129672-84401651 bp, + strand  Genetic Position: Chr11, 51.29 cM
Germline Transmission:  Earliest citation of germline transmission: J:253561
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe targeting vector contains a loxP site inserted in intron 21 and a loxP-flanked neomycin cassette inserted in intron 26. (J:253561)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acaca Mutation:  12 strains or lines available
Original:  J:253561 Kim CW, et al., Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation. Cell Metab. 2017 Aug 1;26(2):394-406.e6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory