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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Jurgen Ruland
MGI ID: MGI:5908402
Synonyms: CARD11(L225LI)stopFL
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:228288
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, Constitutively active, Epitope tag, Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld expresses 1 gene
Mutation detailsA construct containing a slice acceptor site, floxed-neo-stop cassette, HA-tagged human CARD11 cDNA with an isoleucine codon after the leucine codon at position 225 (L225LI), IRES-eGFP cassette and polyA sequence was inserted in intron 1. The human cDNA was derived from a diffuse large B-cell lymphoma and carries a constitutively active mutation. (J:228288)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  512 strains or lines available
Original:  J:228288 Knies N, et al., Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-kappaB and JNK activation. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7230-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory