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Tg(Myh6-POLG*Y955C)DWcc
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-POLG*Y955C)DWcc
Name: transgene insertion D, William C Copeland
MGI ID: MGI:5908193
Synonyms: Y955C TG
Transgene: Tg(Myh6-POLG*Y955C)DWcc  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-POLG*Y955C)DWcc expresses 1 gene
 
Mutation detailsThe human cDNA containing the Y955C mutation seen in patients with chronic progressive external ophthalmoplegia is under the control of the alpha-myosin heavy chain promoter. Four lines were established: B, C, D and E. Line D is entered as the representative line. (J:122507)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:122507 Lewis W, et al., Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma. Lab Invest. 2007 Apr;87(4):326-35
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory