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Mcm3tm1.2Geno
Targeted Allele Detail
Nomenclature
Symbol: Mcm3tm1.2Geno
Name: minichromosome maintenance complex component 3; targeted mutation 1.2, Genoway
MGI ID: MGI:5907492
Synonyms: Mcm3-
Gene: Mcm3  Location: Chr1:20802968-20820312 bp, - strand  Genetic Position: Chr1, 6.5 cM, cytoband A3-A5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:227638
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted in intron 13 and IRES-EGFP-Luciferase cassette, FRT flanked neo cassette and loxP site were inserted after the stop codon in exon 17. Recombinase mediated recombination removed exons 14-17 and the reporter and neo cassettes. (J:227638)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mcm3 Mutation:  2 strains or lines available
References
Original:  J:227638 Alvarez S, et al., Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality. Nat Commun. 2015;6:8548
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory