Mir218-1^em1Slp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir218-1^em1Slp
• Name: microRNA 218-1; endonuclease-mediated mutation 1, Samuel L Pfaff
• MGI ID: MGI:5906822
• Gene: Mir218-1 Location: Chr5:48381284-48381393 bp, + strand Genetic Position: Chr5, 26.17 cM
• Alliance: Mir218-1^em1Slp page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 359bp deletion encompassing the microRNA was created using CRISPR/Cas9. Expression of Mir218 is reduced in single homozygotes and eliminated in mice homozygous for both this allele and Mir218-2^em1Slp (J:227113)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir218-1 Mutation: 0 strains or lines available

References

• Original: J:227113 Amin ND, et al., Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure. Science. 2015 Dec 18;350(6267):1525-9
• All: 2 reference(s)