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Nsmce2tm2.1Ofc
Targeted Allele Detail
Nomenclature
Symbol: Nsmce2tm2.1Ofc
Name: NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase; targeted mutation 2.1, Oscar Fernandez-Capetillo
MGI ID: MGI:5906664
Synonyms: Nsmce2lox
Gene: Nsmce2  Location: Chr15:59374247-59601684 bp, + strand  Genetic Position: Chr15, 25.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:227197
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 3 was flanked with loxP sites and an FRT flanked pgk-neo cassette was inserted in intron 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:227197)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nsmce2 Mutation:  35 strains or lines available
References
Original:  J:227197 Jacome A, et al., NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. EMBO J. 2015 Nov 3;34(21):2604-19
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory