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Cdk12tm1.2Mjfn
Targeted Allele Detail
Nomenclature
Symbol: Cdk12tm1.2Mjfn
Name: cyclin-dependent kinase 12; targeted mutation 1.2, Ming-Ji Fann
MGI ID: MGI:5906608
Gene: Cdk12  Location: Chr11:98203059-98278504 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:242195
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 and 4 were floxed and an FRT flanked neo cassette was inserted via homologous recombination. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exons 3 and 4. The predicted product lacks the kinase domain. (J:242195)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 15 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdk12 Mutation:  16 strains or lines available
References
Original:  J:242195 Juan HC, et al., Cdk12 is essential for embryonic development and the maintenance of genomic stability. Cell Death Differ. 2016 Jun;23(6):1038-48
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory