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Hand2os1em1Eno
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Hand2os1em1Eno
Name: Hand2, opposite strand 1; endonuclease-mediated mutation 1, Eric N Olson
MGI ID: MGI:5906350
Gene: Hand2os1  Location: Chr8:57304414-57320859 bp, - strand  Genetic Position: Chr8, Syntenic
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Insertion
 
Mutation detailsTALEN technology inserted a triple adenylation sequence into exon 2. QPCR confirmed the absence of transcript expression in E10.5 hearts. (J:241318)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 15 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hand2os1 Mutation:  0 strains or lines available
References
Original:  J:241318 Anderson KM, et al., Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development. Nature. 2016 Nov 17;539(7629):433-436
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory