About   Help   FAQ
Tg(Myh6-Tpm1*E54K)30Dfw
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-Tpm1*E54K)30Dfw
Name: transgene insertion 30, David F Wieczorek
MGI ID: MGI:5906016
Synonyms: alpha-TM54
Transgene: Tg(Myh6-Tpm1*E54K)30Dfw  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Tpm1*E54K)30Dfw expresses 1 gene
 
Mutation detailsThe cardiac specific mouse alpha-MHC promoter drives the expression of a mouse mutant alpha-tropomyosin striated muscle specific cDNA with a single nucleotide change, GAA>AAA, corresponding to an amino acid substitution of a glutamic acid to lysine at codon 54 (Glu54Lys). Five lines were generated; 67, 71, 76, 95, and 30. This line has a copy number of approximately 174 and is the high-expressing line. (J:137813)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:137813 Rajan S, et al., Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res. 2007 Jul 20;101(2):205-14
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2022
MGI 6.20
The Jackson Laboratory