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Zeb1tm1.2Mpst
Targeted Allele Detail
Summary
Symbol: Zeb1tm1.2Mpst
Name: zinc finger E-box binding homeobox 1; targeted mutation 1.2, Marc Stemmler
MGI ID: MGI:5901940
Synonyms: Zeb1del
Gene: Zeb1  Location: Chr18:5591860-5775467 bp, + strand  Genetic Position: Chr18, 4.42 cM
Alliance: Zeb1tm1.2Mpst page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:239147
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 6. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette and left exon 6 floxed. Cre-mediated recombination removed exon 6. (J:239147)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 18 assay results
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zeb1 Mutation:  64 strains or lines available
References
Original:  J:239147 Brabletz S, et al., Generation and characterization of mice for conditional inactivation of Zeb1. Genesis. 2017 Apr;55(4)
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory