Mpzl3^tm1Tacz
Targeted Allele Detail

Summary

• Symbol: Mpzl3^tm1Tacz
• Name: myelin protein zero-like 3; targeted mutation 1, Traci A Czyzyk
• MGI ID: MGI:5898283
• Gene: Mpzl3 Location: Chr9:44966484-44988734 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: Mpzl3^tm1Tacz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199257
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LacZ-neo resistance cassette replaced 246 bp of the gene via homologous recombination deleting exon 3. qPCR analysis using a probe spanning exon 2/3 boundary failed to detect product. (J:199257)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpzl3 Mutation: 31 strains or lines available

References

• Original: J:199257 Czyzyk TA, et al., Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis. Am J Physiol Endocrinol Metab. 2013 Jul;305(2):E282-92
• All: 1 reference(s)