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Tg(CAG-Ppard*E411P)#Als
Transgene Detail
Nomenclature
Symbol: Tg(CAG-Ppard*E411P)#Als
Name: transgene insertion, Albert R La Spada
MGI ID: MGI:5897172
Synonyms: PpardE411P
Transgene: Tg(CAG-Ppard*E411P)#Als  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Conditional ready, Dominant negative, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-Ppard*E411P)#Als expresses 1 gene
 
Mutation detailsThis transgene consists of a combined beta-actin promoter-cytomegalovirus enhancer, a STOP cassette flanked by loxP sites and the mouse Ppard cDNA with a single amino acid mutation, a substitution of proline for glutamate at residue 411 (E411P). Cre-mediated recombination can be used to remove the STOP cassette and express the mutant protein. This mutation inhibits Ppard transactivation in a dominant-negative manner. (J:233176)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:233176 Dickey AS, et al., PPAR-delta is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically. Nat Med. 2016 Jan;22(1):37-45
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory