Amtn^tm1Tigm
Targeted Allele Detail

Summary

• Symbol: Amtn^tm1Tigm
• Name: amelotin; targeted mutation 1, Texas Institute for Genomic Medicine
• MGI ID: MGI:5896933
• Gene: Amtn Location: Chr5:88523967-88533775 bp, + strand Genetic Position: Chr5, 43.56 cM, cytoband E2
• Alliance: Amtn^tm1Tigm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240990
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ/neo cassette replaced the sequence encoding the translation start site in exon 2. Absence of the transcript and encoded protein in homozygous animals was confirmed by real-time PCR as well as by Western blotting and immunohistochemistry experiments, respectively. (J:240990)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Amtn Mutation: 14 strains or lines available

References

• Original: J:240990 Nakayama Y, et al., Enamel Hypomineralization and Structural Defects in Amelotin-deficient Mice. J Dent Res. 2015 May;94(5):697-705
• All: 2 reference(s)