Cdkl5^tm1.2Joez
Targeted Allele Detail

Summary

• Symbol: Cdkl5^tm1.2Joez
• Name: cyclin dependent kinase like 5; targeted mutation 1.2, Zhaolan Zhou
• MGI ID: MGI:5896326
• Synonyms: Cdkl15^flox
• Gene: Cdkl5 Location: ChrX:159567304-159777677 bp, - strand Genetic Position: ChrX, 73.95 cM
• Alliance: Cdkl5^tm1.2Joez page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193172
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 6. A loxP site was inserted downstream of exon 6. Cre-mediated recombination removed the neo cassette, but not exon 6. (J:193172)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkl5 Mutation: 19 strains or lines available

References

• Original: J:193172 Wang IT, et al., Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21516-21
• All: 6 reference(s)