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Targeted Allele Detail
Symbol: Cdkl5tm1.2Joez
Name: cyclin-dependent kinase-like 5; targeted mutation 1.2, Zhaolan Zhou
MGI ID: MGI:5896326
Synonyms: Cdkl15flox
Gene: Cdkl5  Location: ChrX:160784308-160994681 bp, - strand  Genetic Position: ChrX, 73.95 cM
Germline Transmission:  Earliest citation of germline transmission: J:193172
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation details A floxed neo cassette was inserted upstream of exon 6. A loxP site was inserted downstream of exon 6. Cre-mediated recombination removed the neo cassette, but not exon 6. (J:193172)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkl5 Mutation:  13 strains or lines available
Original:  J:193172 Wang IT, et al., Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21516-21
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory