Gfra1^{tm1.1(GFRA1*)Bnap}
Targeted Allele Detail

Summary

• Symbol: Gfra1^{tm1.1(GFRA1*)Bnap}
• Name: glial cell line derived neurotrophic factor family receptor alpha 1; targeted mutation 1.1, Brian A Pierchala
• MGI ID: MGI:5888920
• Synonyms: Gfralpha1^TM
• Gene: Gfra1 Location: Chr19:58224036-58444341 bp, - strand Genetic Position: Chr19, 54.18 cM, cytoband D2-D3
• Alliance: Gfra1^{tm1.1(GFRA1*)Bnap} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226474
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Gfra1^{tm1.1(GFRA1*)Bnap} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GFRA1 (2674)

  Gfra1

  (MGI:1100842)

  a transmembrance domain replaces the GPI anchor

• Mutation details: The targeting construct inserted upstream of the coding sequence the human GFRA1 cDNA with a transmembrane domain instead of the GPI anchor. A self-excising floxed neomycin resistance cassette is lacking in the final allele. Endogenous gene expression is disrupted. (J:226474)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfra1 Mutation: 33 strains or lines available

References

• Original: J:226474 Tsui CC, et al., Lipid Rafts Are Physiologic Membrane Microdomains Necessary for the Morphogenic and Developmental Functions of Glial Cell Line-Derived Neurotrophic Factor In Vivo. J Neurosci. 2015 Sep 23;35(38):13233-43
• All: 1 reference(s)