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Tgfbitm1.1Nap
Targeted Allele Detail
Nomenclature
Symbol: Tgfbitm1.1Nap
Name: transforming growth factor, beta induced; targeted mutation 1.1, Nathalie Allaman-Pillet
MGI ID: MGI:5888672
Synonyms: Bigh3-
Gene: Tgfbi  Location: Chr13:56609586-56639359 bp, + strand  Genetic Position: Chr13, 30.09 cM, cytoband B-C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:230752
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 1. Cre-mediated recombination removed the selection cassette and exon 1. Western blotting and immunohistochemistry confirmed the absence of protein (even of a smaller size) in the cornea of homozygous mutant mice. (J:230754)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfbi Mutation:  1 strain or line available
References
Original:  J:230754 Allaman-Pillet N, et al., Tgfbi/Bigh3 silencing activates ERK in mouse retina. Exp Eye Res. 2015 Nov;140:159-70
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory