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Cpeb2tm1.2Yshu
Targeted Allele Detail
Nomenclature
Symbol: Cpeb2tm1.2Yshu
Name: cytoplasmic polyadenylation element binding protein 2; targeted mutation 1.2, Yi-Shuian Huang
MGI ID: MGI:5882111
Synonyms: Cpeb2KO, Cpeb2-KO
Gene: Cpeb2  Location: Chr5:43233170-43289724 bp, + strand  Genetic Position: Chr5, 23.65 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:237513
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA single loxP site is inserted 3' to exon 5. An Frt-PGK-Neo-Frt-loxP cassette was inserted to the 5'-end of exon 3. The neo cassette was removed by crossing to mice carrying the Frt recombinase driven by the beta-actin promoter, leaving single loxP sites flanking exons 3-5. Cre-mediated recombination resulted in excision of exons 3-5. Western blot analysis confirmed the absence of protein in homozygous mutant tissues. (J:237513)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cpeb2 Mutation:  24 strains or lines available
References
Original:  J:237513 Lai YT, et al., Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction. J Neurosci. 2016 Dec 14;36(50):12661-12676
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory