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Slc13a4tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Summary
Symbol: Slc13a4tm1c(EUCOMM)Wtsi
Name: solute carrier family 13 (sodium/sulfate symporters), member 4; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5881936
Synonyms: Slc13a4Flx
Gene: Slc13a4  Location: Chr6:35244888-35285061 bp, - strand  Genetic Position: Chr6, 15.26 cM
Alliance: Slc13a4tm1c(EUCOMM)Wtsi page
IMPC: Slc13a4 gene page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:239786
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 35266501 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 35267312. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:239786)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc13a4 Mutation:  34 strains or lines available
References
Original:  J:239786 Rakoczy J, et al., Loss of the sulfate transporter Slc13a4 in placenta causes severe fetal abnormalities and death in mice. Cell Res. 2015 Nov;25(11):1273-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory