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Slc6a8tm1.2Lbar
Targeted Allele Detail
Nomenclature
Symbol: Slc6a8tm1.2Lbar
Name: solute carrier family 6 (neurotransmitter transporter, creatine), member 8; targeted mutation 1.2, Laura Baroncelli
MGI ID: MGI:5825019
Synonyms: CrT-
Gene: Slc6a8  Location: ChrX:73673150-73682502 bp, + strand  Genetic Position: ChrX, 37.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:232606
Parent Cell Line:  A8 (ES Cell)
Strain of Origin:  (C57BL/6 x 129P2/OlaHsd)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA reporter knock-out allele was generated via cre-mediated recombination which removed the floxed exons 5-7 and left an FRT site, followed by lacZ sequence and a loxP site upstream of the deleted exons. (J:232606)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a8 Mutation:  6 strains or lines available
Notes
ES cells used for allele generation: clone A8, gift fromA. Wutz, Wellcome Trust Centre for Stem Cell Research, Stem Cell Institute, University of Cambridge (J:232606).
References
Original:  J:232606 Baroncelli L, et al., A novel mouse model of creatine transporter deficiency. F1000Res. 2014;3:228
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory