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Slc6a8tm1.1Lbar
Targeted Allele Detail
Nomenclature
Symbol: Slc6a8tm1.1Lbar
Name: solute carrier family 6 (neurotransmitter transporter, creatine), member 8; targeted mutation 1.1, Laura Baroncelli
MGI ID: MGI:5825018
Synonyms: Slc6a8fl
Gene: Slc6a8  Location: ChrX:73673150-73682502 bp, + strand  Genetic Position: ChrX, 37.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:232606
Parent Cell Line:  A8 (ES Cell)
Strain of Origin:  (C57BL/6 x 129P2/OlaHsd)F1
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA conditional ready (floxed) allele was created by removing the FRT-flanked lacZ sequence, loxP site, neomycin cassette under the control of the human beta-actin promoter and SV40 polyA via flp-mediated recombination, and leaving exons 5-7 flanked by loxP sites. (J:232606)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a8 Mutation:  8 strains or lines available
Notes
ES cells used for allele generation: clone A8, gift fromA. Wutz, Wellcome Trust Centre for Stem Cell Research, Stem Cell Institute, University of Cambridge (J:232606).
References
Original:  J:232606 Baroncelli L, et al., A novel mouse model of creatine transporter deficiency. F1000Res. 2014;3:228
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory