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Targeted Allele Detail
Symbol: Pdcd6iptm1.2Adz
Name: programmed cell death 6 interacting protein; targeted mutation 1.2, Alessandra d'Azzo
MGI ID: MGI:5824749
Synonyms: Alix-
Gene: Pdcd6ip  Location: Chr9:113651744-113708259 bp, - strand  Genetic Position: Chr9, 64.03 cM, cytoband F2
Pdcd6iptm1.2Adz/Pdcd6iptm1.2Adz mice develop bilateral hydrocephalus

Show the 8 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:238436
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsOne loxP site was inserted just upstream of exon 2 and a second loxP site 61 bp into exon 3. An FRT flanked neomycin resistance gene cassette was inserted into intron 1. Flp mediated recombination removed the neo cassette. The sequence representing exon 2 through most of exon 3 was deleted through cre-mediated recombination. Western blot analysis confirmed the absence of protein expression in brain, lung, liver, pancreas, and thymus lysates from homozygous mutant mice. (J:238436)
Generation of the Pdcd6iptm1.2Adz allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdcd6ip Mutation:  3 strains or lines available
Original:  J:238436 Campos Y, et al., Alix-mediated assembly of the actomyosin-tight junction polarity complex preserves epithelial polarity and epithelial barrier. Nat Commun. 2016 Jun 23;7:11876
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory