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Nalcntm1c(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Nalcntm1c(KOMP)Wtsi
Name: sodium leak channel, non-selective; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5823777
Synonyms: Nalcnflox, NALCNfx
Gene: Nalcn  Location: Chr14:123276634-123627144 bp, - strand  Genetic Position: Chr14, 66.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:238767
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 123593515 of Chromosome 14 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 123592481. The "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving the critical exons flanked by loxP sites. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:238767)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nalcn Mutation:  6 strains or lines available
References
Original:  J:238767 Flourakis M, et al., A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability. Cell. 2015 Aug 13;162(4):836-48
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory