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Tg(PMP22)C3Fbas
Transgene Detail
Nomenclature
Symbol: Tg(PMP22)C3Fbas
Name: transgene insertion C3, Frank Baas
MGI ID: MGI:5817396
Synonyms: C3-PMP
Transgene: Tg(PMP22)C3Fbas  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x CBA/Ca)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(PMP22)C3Fbas expresses 1 gene
 
Mutation detailsA yeast artificial chromosome (YAC) library was used to obtain a 560 kb BAC (49G7, also called 49H7) containing the entire human peripheral myelin protein 22 (PMP22) gene. Line C3 is derived from founder line C22 and carries 3-4 copies of the YAC, resulting in a milder phenotype than the higer copy number C22 mice. Overexpression of PMP22 is associated with Charcot-Marie-Tooth disease type 1A (CMT1A). (J:237901)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:237901 Verhamme C, et al., Myelin and axon pathology in a long-term study of PMP22-overexpressing mice. J Neuropathol Exp Neurol. 2011 May;70(5):386-98
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory