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Ccp110tm1.2Asw
Targeted Allele Detail
Nomenclature
Symbol: Ccp110tm1.2Asw
Name: centriolar coiled coil protein 110; targeted mutation 1.2, Anand Swaroop
MGI ID: MGI:5816715
Synonyms: Cp110-
Gene: Ccp110  Location: Chr7:118712552-118737024 bp, + strand  Genetic Position: Chr7, 63.58 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:232855
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 5 was flanked by loxP sites. An FRT-flanked neomycin selection cassette was removed by breeding heterozygous floxed animals with actin-Flp recombinase mice, and the loxP-flanked exon 5 sequences were removed by breeding with zona pellucida promoter-driven Cre mice which express Cre in developing oocytes. Immunoblot analysis using anti-CP110 antibody on protein extracts confirmed the absence of protein expression in E14.5 homozygous mutant embryos. (J:232855)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 22 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccp110 Mutation:  4 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Short Rib-Polydactyly Syndrome (J:232855).
References
Original:  J:232855 Yadav SP, et al., Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis. Development. 2016 May 1;143(9):1491-501
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory