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Rai1tm2.1Luo
Targeted Allele Detail
Nomenclature
Symbol: Rai1tm2.1Luo
Name: retinoic acid induced 1; targeted mutation 2.1, Liqun Luo
MGI ID: MGI:5816464
Synonyms: Rai1flox, Rai1-flox
Gene: Rai1  Location: Chr11:60105013-60199197 bp, + strand  Genetic Position: Chr11, 37.81 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:237687
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S1/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a FRT5-flanked neo cassette (frt5-pSV40-Neo-pA-frt5) and a loxP site upstream of exon 3, and a loxP downstream of exon 3. Flp-mediated recombination removed the FRT5-flanked neo cassette. (J:237687)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rai1 Mutation:  59 strains or lines available
References
Original:  J:237687 Huang WH, et al., Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome. Neuron. 2016 Oct 19;92(2):392-406
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory