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Snap29tm1b(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Snap29tm1b(EUCOMM)Wtsi
Name: synaptosomal-associated protein 29; targeted mutation 1b, Wellcome Trust Sanger Institute
MGI ID: MGI:5812298
Synonyms: Snap29-
Gene: Snap29  Location: Chr16:17223864-17248690 bp, + strand  Genetic Position: Chr16, 10.79 cM
Mutation
origin
Mutant Cell Line:  EPD0065_4_B10
Germline Transmission:  Earliest citation of germline transmission: J:236759
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_gt0
 
Mutation detailsCre-mediated excision of the parental Snap29tm1a(EUCOMM)Wtsi allele resulted in the removal of the critical exon 2 leaving behind the inserted lacZ/neo cassette. Removal of exon 2 introduces a frameshift with early termination at the eighth codon in Exon 3. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:236759)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snap29 Mutation:  24 strains or lines available
References
Original:  J:236759 Schiller SA, et al., Establishment of Two Mouse Models for CEDNIK Syndrome Reveals the Pivotal Role of SNAP29 in Epidermal Differentiation. J Invest Dermatol. 2016 Mar;136(3):672-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory