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Gt(ROSA)26Sortm2(ATF4)Myz
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm2(ATF4)Myz
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Makoto Miyazaki
MGI ID: MGI:5812282
Synonyms: Rosa26-ATF4loxtg
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm2(ATF4)Myz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:237331
Parent Cell Line:  EC7.1 (ES Cell)
Strain of Origin:  (C57BL/6J x 129X1/SvJ)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm2(ATF4)Myz expresses 1 gene
 
Mutation detailsThe targeting vector containing a loxP site, PGK-puromycin-pA cassette (in reverse transcriptional orientation), 4x SV40-pA STOP, loxP, and FLAG-human ATF4-WPRE-BGH-pA cassette sequence is introduced to the Gt(ROSA)26Sor gene via a FLP recombinase-mediated cassette exchange method. (J:237331)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  935 strains or lines available
References
Original:  J:237331 Masuda M, et al., Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells. JCI Insight. 2016 Nov 03;1(18):e88646
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory