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Lrrk2tm3.1Arte
Targeted Allele Detail
Nomenclature
Symbol: Lrrk2tm3.1Arte
Name: leucine-rich repeat kinase 2; targeted mutation 3.1, TaconicArtemis
MGI ID: MGI:5811334
Synonyms: LRRK2[S910A+S935A]
Gene: Lrrk2  Location: Chr15:91557378-91700323 bp, + strand  Genetic Position: Chr15, 46.07 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:237182
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA targeting vector containing an FRT-flanked PuroR selection cassette was used to insert S910A and S935A point mutations into exon 21. Flp-mediated recombination removed the FRT-flanked PuroR cassette. (J:237182)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrrk2 Mutation:  105 strains or lines available
References
Original:  J:237182 Ito G, et al., Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. Biochem J. 2016 Sep 01;473(17):2671-85
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory