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Tg(tetO-MYC,-OVAL)#Gtgm
Transgene Detail
Nomenclature
Symbol: Tg(tetO-MYC,-OVAL)#Gtgm
Name: transgene insertion, Ines Guetgemann
MGI ID: MGI:5811153
Synonyms: c-myc/OVA tg, Tg(tetO-cmyc/OVA)
Transgene: Tg(tetO-MYC,-OVAL)#Gtgm  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J or C57BL/6J x (C57BL/6J x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgene contains a tetracycline responsive element, comprising seven tandem copies of the tetracycline operator (tetO), driving bidirectional expression of cDNAs encoding human MYC (melanocytomatosis oncogene; also called c-myc)(exons 2-3) and cytosolic chicken ovalbumin (OVAL; also called SERPINB14) from oppositely-oriented human cytomegalovirus (CMV) minimal promoters. (J:186226)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:186226 Ney JT, et al., Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation. Hepatology. 2009 Feb;49(2):471-81
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory