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Targeted Allele Detail
Symbol: Apoetm1.1(APOE*4)Adiuj
Name: apolipoprotein E; targeted mutation 1.1, MODEL-AD Center
MGI ID: MGI:5810209
Synonyms: APOEepsilon4
Gene: Apoe  Location: Chr7:19430034-19433113 bp, - strand  Genetic Position: Chr7, 9.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:300626
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion, Nucleotide substitutions
Apoetm1.1(APOE*4)Adiuj expresses 1 gene
Mutation detailsThe targeting vector contains a 3' FRT flanked neo cassette and 1.5 kb of human APOE gene sequence including exons 2, 3, 4 and a portion of the 3'UTR sequence (the APOE4 isoform) which is used to replace exons 2, 3 and most of exon 4 of the endogenous sequence. The human ApoE sequence carries a 2 nucleotide A to T substitution in intron 3. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:300626)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 36 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  135 strains or lines available
Original:  J:300626 Foley KE, et al., APOE and APOE genotypes drive unique gene signatures in the cortex of young mice. bioRxiv. 2020;
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory