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Rcor2tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Rcor2tm1c(EUCOMM)Wtsi
Name: REST corepressor 2; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5806455
Synonyms: Rcor2fl
Gene: Rcor2  Location: Chr19:7267394-7275225 bp, + strand  Genetic Position: Chr19, 5.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:235702
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 7269328 of Chromosome 19 upstream of the critical exons (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 7271799. The critical exons are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice, removing the lacZ sequence and neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:235702)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rcor2 Mutation:  27 strains or lines available
References
Original:  J:235702 Wang Y, et al., LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nat Commun. 2016;7:10481
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory