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Tcf3tm1(PBX1)Mlc
Targeted Allele Detail
Nomenclature
Symbol: Tcf3tm1(PBX1)Mlc
Name: transcription factor 3; targeted mutation 1, Michael L Cleary
MGI ID: MGI:5806089
Synonyms: Tg(E2A-PBX1)
Gene: Tcf3  Location: Chr10:80409514-80433647 bp, - strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:226241
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tcf3tm1(PBX1)Mlc expresses 1 gene
 
Mutation detailsA loxP site was inserted upstream of exon 13. A neomycin resistance cassette, loxP site, human PBX1a, IRES and EGFP reporter gene were inserted downstream of exon 16. Cre-mediated recombination is required to remove exons 13 through 16 and produce a fusion between the endogenous gene and inserted human sequence. This fusion replicates the t(1;19) chromosomal translocation present in some pediatric acute lymphoblastic leukemia patients. (J:226241)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf3 Mutation:  12 strains or lines available
References
Original:  J:226241 Duque-Afonso J, et al., Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. J Clin Invest. 2015 Sep;125(9):3667-80
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory