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Targeted Allele Detail
Symbol: Tcf3tm1(PBX1)Mlc
Name: transcription factor 3; targeted mutation 1, Michael L Cleary
MGI ID: MGI:5806089
Synonyms: Tg(E2A-PBX1)
Gene: Tcf3  Location: Chr10:80409514-80433647 bp, - strand  Genetic Position: Chr10, 39.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:226241
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Tcf3tm1(PBX1)Mlc expresses 1 gene
Mutation detailsA loxP site was inserted upstream of exon 13. A neomycin resistance cassette, loxP site, human PBX1a, IRES and EGFP reporter gene were inserted downstream of exon 16. Cre-mediated recombination is required to remove exons 13 through 16 and produce a fusion between the endogenous gene and inserted human sequence. This fusion replicates the t(1;19) chromosomal translocation present in some pediatric acute lymphoblastic leukemia patients. (J:226241)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf3 Mutation:  12 strains or lines available
Original:  J:226241 Duque-Afonso J, et al., Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. J Clin Invest. 2015 Sep;125(9):3667-80
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory