Tcf3^tm1(PBX1)Mlc
Targeted Allele Detail

Summary

• Symbol: Tcf3^tm1(PBX1)Mlc
• Name: transcription factor 3; targeted mutation 1, Michael L Cleary
• MGI ID: MGI:5806089
• Synonyms: Tg(E2A-PBX1)
• Gene: Tcf3 Location: Chr10:80245348-80269481 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tcf3^tm1(PBX1)Mlc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226241
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tcf3^tm1(PBX1)Mlc expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PBX1 (5087)

  Pbx1	(MGI:97495)

  Tcf3/PBX1 fusion

• Mutation details: A loxP site was inserted upstream of exon 13. A neomycin resistance cassette, loxP site, human PBX1a, IRES and EGFP reporter gene were inserted downstream of exon 16. Cre-mediated recombination is required to remove exons 13 through 16 and produce a fusion between the endogenous gene and inserted human sequence. This fusion replicates the t(1;19) chromosomal translocation present in some pediatric acute lymphoblastic leukemia patients. (J:226241)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf3 Mutation: 39 strains or lines available

References

• Original: J:226241 Duque-Afonso J, et al., Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. J Clin Invest. 2015 Sep;125(9):3667-80
• All: 2 reference(s)