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Targeted Allele Detail
Symbol: Mir196a-2tm1.1Wtsi
Name: microRNA 196a-2; targeted mutation 1.1, Wellcome Trust Sanger Institute
MGI ID: MGI:5805881
Synonyms: Mir196a-2tm1.1(mirKO)Wtsi
Gene: Mir196a-2  Location: Chr15:102881785-102881869 bp, + strand  Genetic Position: Chr15, 58.04 cM
Mutant Cell Line:  mirKO_ES_PuDtk_13C1
Germline Transmission:  Earliest citation of germline transmission: J:226712
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion     Vector: PGK_EM7_PuDtk_bGHpA
Mutation detailsThe insertion of the PGK_EM7_PuDtk_bGHpA cassette created a deletion of size 79 starting at position 102801587 and ending at position 102801666 of Chromosome 15 (Genome Build 37). This deletion eliminates the DNA sequence for this microRNA. The cassette is composed of a loxP site followed by an F3 site followed by a PGK-puromycin-delta-tk cassette, a loxP site and finally an FRT site. Cre-mediated recombination removed the selection cassette. (J:226712)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mir196a-2 Mutation:  1 strain or line available
Original:  J:226712 Wong SF, et al., Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4884-93
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory