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Ptpn6em1.1Shoy
Endonuclease-mediated Allele Detail
Summary
Symbol: Ptpn6em1.1Shoy
Name: protein tyrosine phosphatase, non-receptor type 6; endonuclease-mediated mutation 1.1, Sho Yamasaki
MGI ID: MGI:5805709
Synonyms: SHP-1S557A
Gene: Ptpn6  Location: Chr6:124697670-124715672 bp, - strand  Genetic Position: Chr6, 59.17 cM
Alliance: Ptpn6em1.1Shoy page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA floxed neomycin resistance cassette inserted upstream of exon 12. Exon 14 was replaced with one in which nucleotide substitution(s) result(s) in the amino acid substitution of alanine for serine at position 557 (S557A). Cre-mediated recombination removed the selection cassette. (J:236298)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpn6 Mutation:  47 strains or lines available
References
Original:  J:236298 Ishikawa E, et al., Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. Nat Commun. 2016 Sep 27;7:12756
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory