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Adam7tm1Tigm
Targeted Allele Detail
Nomenclature
Symbol: Adam7tm1Tigm
Name: a disintegrin and metallopeptidase domain 7; targeted mutation 1, Texas A&M Institute for Genomic Medicine
MGI ID: MGI:5804545
Gene: Adam7  Location: Chr14:68497336-68533689 bp, - strand  Genetic Position: Chr14, 35.69 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:226260
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe beta-geo/puromycin resistance cassette replaced exons 1 and 2. Western blot analysis confirmed the absence of protein expression in the epididymis. (J:226260)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam7 Mutation:  26 strains or lines available
References
Original:  J:226260 Choi H, et al., Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. Biol Reprod. 2015 Sep;93(3):70
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory