Hmga2^tm1.1Mmw
Targeted Allele Detail

Summary

• Symbol: Hmga2^tm1.1Mmw
• Name: high mobility group AT-hook 2; targeted mutation 1.1, Monte Winslow
• MGI ID: MGI:5804455
• Synonyms: Hmga2^CK
• Gene: Hmga2 Location: Chr10:120197180-120312374 bp, - strand Genetic Position: Chr10, 67.94 cM
• Alliance: Hmga2^tm1.1Mmw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211779
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with 3' loxP2272 and loxP5171 site was inserted upstream of exon 2. An inverted EGFP expression cassette with 3' loxP2272 and loxP5171 sites was inserted downstream of exon 2 without affecting Mir763. Flp-mediated recombination removed the selection cassette. (J:211779)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hmga2 Mutation: 12 strains or lines available

References

• Original: J:211779 Chiou SH, et al., A conditional system to specifically link disruption of protein-coding function with reporter expression in mice. Cell Rep. 2014 Jun 26;7(6):2078-86
• All: 4 reference(s)