Ednrbtm1.1Nrd
Targeted Allele Detail
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Symbol: |
Ednrbtm1.1Nrd |
Name: |
endothelin receptor type B; targeted mutation 1.1, Noah Druckenbrod |
MGI ID: |
MGI:5804183 |
Synonyms: |
EdnrB- |
Gene: |
Ednrb Location: Chr14:104052061-104081838 bp, - strand Genetic Position: Chr14, 53.05 cM
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Alliance: |
Ednrbtm1.1Nrd page
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The Ednrbtm1.1Nrd/Ednrbtm1.1Nrd pups are smaller and have black spots due to a melanin pigmentation defect
Show the 2 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A floxed neo cassette was placed upstream of exon 3 and an additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette and exon 3, resulting in an out-of-frame transcript of exon 2-4 splicing. qRT-PCR analysis of RNA isolated from the left and right cardiac ventricles confirmed that expression is absent in homozygous and reduced to approximately half in heterozygous mutant mice.
(J:226561)
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Generation of the Ednrbtm1.1Nrd allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ednrb Mutation: |
103 strains or lines available
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Original: |
J:226561 Stobdan T, et al., Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10425-30 |
All: |
2 reference(s) |
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