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Dnm1tm1.2Frk
Targeted Allele Detail
Nomenclature
Symbol: Dnm1tm1.2Frk
Name: dynamin 1; targeted mutation 1.2, Wayne N Frankel
MGI ID: MGI:5800540
Synonyms: Dnm1deltaa
Gene: Dnm1  Location: Chr2:32198483-32243350 bp, - strand  Genetic Position: Chr2, 22.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:235711
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 10a was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of exon 10a. Cre-mediated recombination removed exon 10a. Western blot analysis confirmed the absence of isoform a but expression of isoform b. (J:235711)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnm1 Mutation:  22 strains or lines available
References
Original:  J:235711 Asinof S, et al., Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy. Neurobiol Dis. 2016 Nov;95:1-11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory