About   Help   FAQ
Wdfy3disc
Chemically induced Allele Detail
Nomenclature
Symbol: Wdfy3disc
Name: WD repeat and FYVE domain containing 3; disconnected
MGI ID: MGI:5795594
Gene: Wdfy3  Location: Chr5:101832956-102069921 bp, - strand  Genetic Position: Chr5, 48.95 cM
Forebrain overgrowth in Wdfy3disc/Wdfy3disc mutants

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU) (Hypomorph)
Mutation:    Single point mutation
 
Mutation detailsThis mutation was identified in a forward genetics screen for mutations affecting forebrain development in mice. A single nonsense mutation in exon 59 of 67 of the Wdfy3 gene (T to A at position 9,683 of NM_172882, aa 3,046 of 3,508) was identified as the causative mutation, and introduces a premature stop codon. (J:225200)
Identification of the Wdfy3disc mutation
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wdfy3 Mutation:  65 strains or lines available
References
Original:  J:225200 Orosco LA, et al., Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. Nat Commun. 2014;5:4692
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory