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Targeted Allele Detail
Symbol: Ptchd1tm2.2Gfng
Name: patched domain containing 1; targeted mutation 2.2, Guoping Feng
MGI ID: MGI:5792687
Gene: Ptchd1  Location: ChrX:155573455-155623814 bp, - strand  Genetic Position: ChrX, 72.38 cM
Germline Transmission:  Earliest citation of germline transmission: J:232709
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector containing a FRT-site flanked NEO selection cassette was used to insert loxP sites flanking exon 2. This selection cassette was inserted downstream of exon 2 of the targeted gene, and another loxP site was inserted upstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2. In situ hybridization confirmed the absence of full-length mRNA in the brain. (J:232709)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptchd1 Mutation:  4 strains or lines available
Original:  J:232709 Wells MF, et al., Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice. Nature. 2016 Apr 7;532(7597):58-63
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory