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Targeted Allele Detail
Symbol: Bmp7tm1.1(cre/ERT2)Grsh
Name: bone morphogenetic protein 7; targeted mutation 1.1, Irina Grishina
MGI ID: MGI:5792123
Synonyms: Bmp7-CreERT2
Gene: Bmp7  Location: Chr2:172709805-172782114 bp, - strand  Genetic Position: Chr2, 95.54 cM
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Mutation detailsA targeting construct was designed to replace exon 1, including the translation start, of the bone morphogenetic protein 7 (Bmp7) gene with a creER fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain). The Cre/ER sequence is followed by a hGHpA cassette (human Growth Hormone polyadenylation signal) and a frt-flanked puromycin resistance (puro) cassette. The chimeric mice were bred to mice expressing FLP Recombinase to remove puro cassette. (J:101977)
 Tissue activity of this recombinase allele
Driver: Bmp7     Summary of all recombinase alleles driven by Bmp7. Comparative matrix view of recombinase activities

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bmp7 Mutation:  24 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
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