Bmp7^{tm1.1(cre/ERT2)Grsh}
Targeted Allele Detail

Summary

• Symbol: Bmp7^{tm1.1(cre/ERT2)Grsh}
• Name: bone morphogenetic protein 7; targeted mutation 1.1, Irina Grishina
• MGI ID: MGI:5792123
• Synonyms: Bmp7-CreERT2
• Gene: Bmp7 Location: Chr2:172709805-172782114 bp, - strand Genetic Position: Chr2, 95.54 cM
• Alliance: Bmp7^{tm1.1(cre/ERT2)Grsh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Bmp7^{tm1.1(cre/ERT2)Grsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Bmp7 (MGI:103302)

• Mutation details: A targeting construct was designed to replace exon 1, including the translation start, of the bone morphogenetic protein 7 (Bmp7) gene with a creER fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain). The Cre/ER sequence is followed by a hGHpA cassette (human Growth Hormone polyadenylation signal) and a frt-flanked puromycin resistance (puro) cassette. The chimeric mice were bred to mice expressing FLP Recombinase to remove puro cassette. (J:101977)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Bmp7 (mouse) Summary of all recombinase alleles driven by Bmp7. Alliance mouse Bmp7 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bmp7 Mutation: 37 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)